Fluent 1010
A clinical trial for an investigational mRNA seasonal flu vaccine
Overview / Background
Seasonal flu can cause serious illness, especially for older people
In winter, seasonal flu can cause thousands of people in the UK to receive hospital treatment every day
The Fluent Trial is looking to recruit more than 56,000 people across Europe, North America and Asia to help research into an investigational mRNA jab against seasonal flu
Researchers at Wansford Research Ltd are recruiting participants > 50 years of age to take part in the Fluent Study. They are randomised to a novel mRNA Investigational vaccine against Influenza or approved Vaccine Influ spit in a 50:50 ratio. Research into potential vaccines that may protect older people against seasonal flu is important. If effective, these vaccines offer one of the most successful ways we can both lower the risk of serious flu-related illness and help reduce the pressure on health and social care services during the winter.”
The Fluent Trial is a Phase 3 clinical trial. This is the last phase before an investigational vaccine can be made available for public use (after approval from the UK Medicines and Healthcare products Regulatory Agency). Phase 3 trials, like the Fluent Trial, evaluate the investigational vaccine in a large group of people.
Process
Everyone taking part in the Fluent Trial will receive a vaccine against seasonal flu. This will either be the investigational vaccine or a separate flu vaccine that is already approved for use. People who do not qualify for an NHS flu vaccine, may still be eligible to receive either an investigational or commercially available flu vaccine in the Fluent Trial.
People taking part in the Fluent Trial must be 50 years of age or older, in good health and not have had seasonal flu within six months of starting the trial.
The clinical trial team will be on hand to support everyone who takes part in the trial. They will also make sure that participants understand the important details about the trial before agreeing to take part. This is called informed consent and includes what the trial involves and any risks.
Outcomes
Additional Information
References:
1. Annual flu programme. UK Health Security Agency. Accessed May 28, 2024. https://www.gov.uk/government/collections/annual-flu-programme
2. Norovirus and flu cases in hospitals surge to a new high this winter. NHS England. Published February 1, 2024. Accessed May 28, 2024. https://www.england.nhs.uk/2024/02/norovirus-and-flu-cases-in-hospitals-surge-to-a-new-high-this-winter/
Recruitment
Target Recruitment 75
Actual Recruitment 94
Get Involved
This study has now concluded.
Would you like to participate in an upcoming study?
Click below to send us your details and a member of the team will be in touch.
